Accelerated Hantzsch electrospray synthesis with temporal control of reaction intermediates.

Accelerated Hantzsch electrospray synthesis with temporal control of reaction intermediates† †Electronic supplementary information (ESI) available: Spectra for all on-line, off-line, and substituent studies as well as photographs of experimental setups are supplied. See DOI: 10.1039/c4sc02436b Click here for additional data file.

One –Pot Synthesis of Polyhydroquinoline Derivatives via Hantzsch Condensation Reaction Using Nanosized Magnesium Oxide as Heterogeneous Catalyst

An efficient, recyclable and environmental-friendly synthetic route to polyhdroquinoline derivatives have been developed via multi-component one-pot Hantzsch reaction of various aromatic aldehyde, 2 equivalents of 5,5-dimethyl-1,3-cyclohexanedione (dimedone), ethyl acetoacetate and ammonium acetate using nano magnesium oxide as a catalyst in ethanol under reflux condition. Reaction with 4-chlor...

Nano Al2O3/KF using for synthesis of some Hantzsch type-products

A protocol for the synthesis of 1,4-dihydropyridines (Hantzsch type-products) was developed by means of a three-component condensation of an aldehyde, a β-dicarbonyl compound, ammonium acetate and nano Al2O3/KF as catalyst. This reaction was carried out under different conditions including i) solvent-free ii) and reflux in different solvents. In all conditions, the desired products were obtaine...

Synthesis of Novel 1,4- Dihydropyridine Derivatives Bearing Biphenyl-2'-Tetrazole Substitution as Potential Dual Angiotensin II Receptors and Calcium Channel Blockers.

INTRODUCTION We report the synthesis of novel 1,4-dihydropyridine derivatives containing biphenyl-2'-tetrazole moieties. We hypothesized that merging the key structural elements present in an AT1 receptor antagonist with key structural elements in 1,4-dihydropyridine calcium channel blockers would yield novel analogs with potential dual activity for both receptors. This strategy led to the desi...

Nanocrystalline TiO2 as an efficient and reusable catalyst for the one-pot synthesis of polyhydroquinolien derivatives via Hantzsch reaction

An efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanocrystalline TiO2 under solvent free conditions. The reported method is mild, rapid and has the advantages su...